Application of the hottest plasticizer ATBC in foo

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Application of plasticizer ATBC in food and medical packaging (Part 1)


plasticized PVC film is widely used in food packaging and medical instruments because of its softness, luster and transparency, certain oxygen permeability, water vapor permeability, low temperature resistance, scratch resistance and other properties. Among the plasticizers used in PVC resin, di (2-ethylhexyl) phthalate (DOP) is the most widely used because of its excellent comprehensive properties. In recent years, the toxicity of DOP has attracted the attention of countries all over the world. Although there is an endless debate about whether it is carcinogenic, the major developed countries in the world have taken corresponding measures because of the potential carcinogenic risk of DOP. On December 7, 1999, the European Union issued a "ban" to prohibit the sale of Polyvinyl chloride (PVC) soft plastic toys and children's articles containing one or more of the six phthalate plasticizers (DINP, DOP, DBP, DIDP, DnOP, BBP) put into the mouth. The EU said that the "ban" placed special emphasis on "ensuring a high level of child health and safety protection". According to the research results of the National Cancer Institute, the industrial production of six new phthalates has been stopped. DOP is only used in food packaging with high water content, and meat packaging must be replaced by other non-toxic plasticizers. As we all know, China is the largest toy export country in the world. Therefore, at present, various electronic circuits are basically used to complete the active measurement and control in this link. The "ban" will directly affect the annual export of 1.4 billion US dollars of toys from Europe and the United States. It can be predicted that the international standards formulated by various countries for PVC containing products will be improved day by day, and the scope of products affected by the "ban" will be increased day by day. If there is no effective response, enterprises will suffer greater losses. Therefore, the research, development and use of non-toxic plasticizers to replace the application of ortho benzene plasticizers in the field of food packaging and medicine has become an important topic in the current plasticizer industry. Citric acid esters, such as tri-n-butyl citrate, acetyl tri-n-butyl citrate, tri (2-ethylhexyl) citrate, are the preferred non-toxic plasticizers, among which acetyl tri-n-butyl citrate (ATBC) is the most widely used, It is one of the few non-toxic plasticizers for food packaging permitted by major developed countries

2 toxicity of tri-n-butyl acetyl citrate

tri-n-butyl acetyl citrate is a non-toxic plasticizer recognized by countries all over the world. According to the data, the hardness is not enough to report. It has no effect on rats and cats by oral exposure at the dose of 10 ~ 30ml/kg. Feed the rats with 5% and 10% of this product respectively for 8 weeks, and no abnormality is found in the main organs. Only at the concentration of 10%, the growth of rats slows down due to diarrhea. As for the toxicity of ATBC, many people abroad have done chronic toxicological tests, which also show that: tri-n-butyl acetylcitrate, whether in acute, chronic or subacute tests, will not cause the pathological process of obviously sealing the oil delivery valve, and it can be considered as a non-toxic substance. Table 1 lists the safe daily intake (ADI) of ATBC per person, as well as the commonly used ADI values of DOP and DBP

it can be seen from table 1 that the ADI value of ATBC is 10 times larger than the DOP and DBP most commonly used in PVC products used in food packaging and medical appliances in China, indicating that the application of ATBC in these fields is safe. In view of the low toxicity of acetyl tri-n-butyl citrate, the U.S. Food and Drug Administration (FDA) approved it not only as a plastic plasticizer for food packaging and medical appliances, but also as a food additive (synthetic flavor)

(to be continued)

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